Best mouthwash for periodontal disease

Dealing with periodontal disease requires a comprehensive approach that goes beyond just brushing. Incorporating an effective antiseptic mouthwash into your oral care routine can significantly contribute to controlling harmful bacteria and reducing inflammation.

Periodontitis, a severe form of gum disease, demands more than just regular brushing. It involves inflammation and infection that affect the tissues supporting teeth, potentially leading to tooth loss if left untreated.

While professional dental interventions are crucial, maintaining good oral hygiene at home is equally vital. Antiseptic mouthwashes can play a significant role by targeting bacteria, minimizing inflammation, and aiding in the overall management of periodontal infections.

These specialized rinses work in synergy with professional treatments and regular brushing to provide optimal periodontal care.

Best mouthwash for periodontal disease

Reviews of mouthwash for gum disease

Here are some highly effective mouthwash options tailored for individuals dealing with gum disease:

1. Listerine Cool Mint Antiseptic

The iconic Listerine formula is packed with essential oils known for their potent antibacterial and antimicrobial properties. These ingredients have been clinically proven to reduce plaque buildup and the incidence of gingivitis. While the ethanol-based formula provides strong germ-killing abilities, it’s worth noting that some users might experience an initial burning sensation.

2. Crest Pro-Health Advanced Multi-Protection

Crest offers an alcohol-free alternative that utilizes CPC (cetylpyridinium chloride) technology. This technology effectively targets and eliminates germs while simultaneously soothing inflamed gums. The antimicrobial action not only reduces bacteria but also incorporates fluoride to strengthen tooth enamel against the corrosive effects of plaque-induced acids.

3. PerioMed Anti-Plaque Antiseptic

PerioMed contains cetylpyridinium chloride, a powerful agent against the bacteria responsible for gingivitis. Clinical evidence supports its effectiveness in reducing both plaque buildup and gingival index scores in patients with periodontal issues. Notably, this mouthwash offers a pleasant taste without the potential discomfort of alcohol burn.

4. PerioShield Oral Rinse with Oxygene Formula

This innovative rinse uses chlorine dioxide to hinder the growth of bacteria and neutralize volatile sulfur compounds that contribute to bad breath. By creating an unfavorable environment for anaerobic bacteria, this mouthwash helps maintain a healthier oral balance.

5. TheraBreath PerioTherapy

In addition to oxygenating components, TheraBreath’s PerioTherapy mouthwash contains cetylpyridinium chloride, which specifically targets pathogenic bacteria associated with periodontal disease. It aids in restoring a balanced and healthy microflora in the mouth.

Finding the right product for your case

Periodontal disease, affecting a significant portion of the global population, emphasizes the importance of effective oral hygiene. Mechanical plaque control is crucial, but chemical agents in toothpastes and mouthwashes provide supplementary benefits.

Some common compounds found in mouthwash that help in promoting oral health and combating periodontal diseases include:

1. Chlorhexidine (CHX)

CHX, an anti-plaque and anti-gingivitis agent, is considered the “gold standard” in chemical plaque control. It possesses bacteriostatic and bactericidal properties. CHX’s cationic nature enables it to bind to bacteria’s membrane phospholipids, leading to antimicrobial effects.

Comparative studies reveal that a 0.2% CHX mouthwash exhibits superior plaque prevention.

  • The 0.2% CHX mouthwash effectively controls gingivitis and the gingival index.
  • CHX outperforms essential oil-based mouthwashes in terms of anti-biofilm and anti-gingivitis properties.
  • CHX combined with fluoride offers improved anti-plaque efficacy and reduced staining.
  • CHX in combination with anti-biofilm peptides or systemic antibiotics enhances bacterial control.
  • Innovations like low-intensity direct current and nanotechnology optimize CHX’s efficacy.

2. Cetylpyridinium Chloride (CPC)

CPC exhibits broad-spectrum antibacterial and antiviral effects. Combined with toothbrushing, CPC mouth rinses reduce plaque and gingival inflammation.

3. Fluorides

Fluorides prevent dental caries and promote enamel remineralization. Recent research highlights their antibacterial and cariostatic properties, crucial for periodontal health. Stannous Fluoride, SnF2, reduces plaque, gingivitis, staining, and halitosis. It exhibits direct and indirect anti-inflammatory actions. SnF2 stimulates periodontal ligament cell proliferation and mineralization, suggesting regenerative potential.

4. Stannous Chloride (SnCl2)

SnCl2’s anti-erosive and antiseptic properties contribute to oral care. Stannous compounds hold promise for periodontal health. Their diverse benefits pave the way for novel oral care strategies.

5. Zinc

Zinc’s antibacterial properties combat plaque and reduce calculus formation. Zinc salts in toothpastes and mouth rinses control plaque, malodor, and calculus. Zinc’s role in remineralization and enamel solubility reduction is noted.

6. Herbal Components

Licorice’s antimicrobial, anti-inflammatory, and immunoregulatory properties make it promising for oral care.

Final Note 

When selecting a mouthwash for managing periodontal disease, it’s advisable to consult your dentist or hygienist. They can provide personalized recommendations based on your specific oral health needs and the severity of your condition.

Keep in mind that the combination of professional treatments and diligent at-home care is essential for effectively managing periodontal infections.


  • Editorial team

    A team comprising oral health care professionals, researchers, and professional Writers, striving to impart you with the knowledge to improve your oral health, and that of your loved ones. 

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